CacSFMs: Citric Acid Cycle Binding Structural & Functional Motifs - v. β May 2016.
© University Dr Tahar Moulay, Saida.



Project realized by:Abdalla Salem and Mubarka Khatir (in their project of MSc in Biology, 2015-2016)

Proposed & supervised by: Dr. Abdelkrim Rachedi, e-mail: rachedi@bioinformaticstools.org

Reference: SALEM Abdellahi, RACHEDI Abdelkrim. STRUCTURAL/FUNCTIONAL MOTIFS IN THE ENZYMES OF THE KREBS CYCLE, 1ER SEMINAIRE DE BIOINFORMATIQUE, April 04-06, 2017, Blida, Algeria.

Citric Acid Cycle Binding Structural & Functional Motifs
- CacSFMs database-
Find CAC SFMs by Enzymes
   << Click on the list to find out ..
Find CAC SFMs by PDB entries
1AJ8   1IXE   2C6X   2P2W   2R9E   6CSC   1ACO   1FGH   1L5J   1ITW   1XKD   2UXR   4AJ3   4AJB   4BNP   3INM   4L06   4L04   4L03   4KZO   4AJR   4AJC   3O9Z   1CW4   2BWO   2BWN   2W8Q   4LH2   2DJL   3JU8   4APB   2DFD   
   << Click on the list to find out ..
Find CAC SFMs by Ligands
CIT   FLC   SDX   TRA   ATH   ICT   AKG   SCA   SIN   FUM   MLT   
   << Click on the list to find out ..
Ligand: IDFull NameFormula Chemistry
ICTISOCITRIC ACIDC6 H8 O7ICT
There are 12 SFM Motifs:
Nbr of Motifs
per PDB entry
PDB EntryTitleDetermination MethodResolutionR-Factor
41ITWIsocitrate dehydrogenaseX-RAY1.950.193
Motif No./ChainModeBound Ligand
/(Nbr. in PDB)
Show Details
1 / A   > Structure: LHSLLHHHL +5w
  > Sequence: SNRRKMDYRDA
ICT
/(743)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
2 / B   > Structure: LHSLLHHHL +5w
  > Sequence: SNRRKMDYRDA
ICT
/(744)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
3 / C   > Structure: LHSLLHHHL +5w
  > Sequence: SNRRKMDYRDA
ICT
/(743)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
4 / D   > Structure: LHSLLHHHL +5w
  > Sequence: SNRRKMDYRDA
ICT
/(743)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
Nbr of Motifs
per PDB entry
PDB EntryTitleDetermination MethodResolutionR-Factor
21XKDIsocitrate dehydrogenaseX-RAY2.300.226
Motif No./ChainModeBound Ligand
/(Nbr. in PDB)
Show Details
1 / A   > Structure: SSHH +1w
  > Sequence: RRYD
ICT
/(1002)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
2 / B   > Structure: LHSSHHL +1w
  > Sequence: TSNVRRRYDV
ICT
/(1004)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
Nbr of Motifs
per PDB entry
PDB EntryTitleDetermination MethodResolutionR-Factor
32UXRIsocitrate dehydrogenaseX-RAY2.300.195
Motif No./ChainModeBound Ligand
/(Nbr. in PDB)
Show Details
1 / A   > Structure: SSHHLLH +2w
  > Sequence: TSNRRRYDA
ICT
/(1403)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
2 / A   > Structure: LLHL +1w
  > Sequence: LHGVHTN
ICT
/(1404)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
3 / B   > Structure: SSHHSLLH +1w
  > Sequence: TSNRRRYDEA
ICT
/(1397)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
Nbr of Motifs
per PDB entry
PDB EntryTitleDetermination MethodResolutionR-Factor
14AJ3Isocitrate dehydrogenaseX-RAY1.900.189
Motif No./ChainModeBound Ligand
/(Nbr. in PDB)
Show Details
1 / A   > Structure: LHSSHH
  > Sequence: TSNRRRYD
ICT
/(1418)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
Nbr of Motifs
per PDB entry
PDB EntryTitleDetermination MethodResolutionR-Factor
14AJBIsocitrate dehydrogenaseX-RAY1.800.183
Motif No./ChainModeBound Ligand
/(Nbr. in PDB)
Show Details
1 / A   > Structure: HSSHH +4w
  > Sequence: SRRRYD
ICT
/(502)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
Nbr of Motifs
per PDB entry
PDB EntryTitleDetermination MethodResolutionR-Factor
14BNPIsocitrate dehydrogenaseX-RAY2.000.163
Motif No./ChainModeBound Ligand
/(Nbr. in PDB)
Show Details
1 / A   > Structure: HSSHH +5w
  > Sequence: SNRRRYD
ICT
/(502)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]